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Experimental increase in baseline corticosterone level reduces oxidative damage and enhances innate immune response

One important feature of mitochondrial permeabilization is the loss of function resulting in the inability of mitochondria to synthesize ATP through the OXPHOS

p = 0.011

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In other words, functional wild-type p53 promotes a cancer-suppressing TME in tumor cells, whereas a decrease in or loss of wild-type p53 promotes a cancer-promoting TME in tumor cells